The PRS Signature Series includes signature models from famous guitarists who play PRS guitars. Paul Reed Smith understood the value of endorsement from early on - Carlos Santana's PRS model helped propel PRS to global recognition. Other PRS signature guitarists include John Mayer, Mark Tremonti, Myles Kennedy, Mark Holcomb and Zach Myers. All of these musicians have signature models available as part of the PRS Artist Series such as the John Mayer Silver Sky and the semi-hollow SE Zach Myers.

PRS Signature Series guitars span different designs from single cut and double cut body shapes available with a range of pickup configurations, and are suited to various styles of music, from blues and rock to metal and jazz. PRS Artist Package models provide additional features and colours not found on standard catalogue models. They also spanning a number of price points - with more affordable SE versions also available.